Sentence examples for issues of specificity from inspiring English sources
The development of tumour-specific contrast agents may provide a simple answer to the issues of specificity.
If used prospectively, however, to look across drugs at patterns of prescribing and outcomes, careful attention would need to be paid to issues of specificity and multiple testing.
However, this technique depends on the use of antibodies to recognize the target protein of interest, and as with all techniques that rely on antibodies, issues of specificity and affinity arise.
The clearance of bulky DNA adducts is somewhat longer, as might be expected, with half-lives lasting up to 10 12 weeks; but again there are issues of specificity with these biomarkers (Godschalk et al., 2003).
However, its antibody-centric nature exposes it to similar challenges faced by other antibody-based procedures, of which the most prominent are issues of specificity and affinity in antigen recognition.
Thus, we were unable to ascertain whether phospho-SMAD expression is intact or diminished in Megf8 null embryos (which would imply that Megf8 modifies BMP4 signaling via a non-SMAD dependent mechanism), or if we could not observe a difference that was present because of issues of specificity or because this assay would not allow us to detect subtle changes in phospho-SMAD levels.
A number of reports have raised the issue of specificity and efficiency of gene transfer [ 3, 4], specifically to neoplastic cells.
However, more recently, the issue of specificity has been questioned as several groups have demonstrated that various mismatches between the guide strand of the siRNA and the mRNA target do not abolish the silencing effect of the siRNA [37], [38].
For genome-editing techniques, the issue of specificity and delivery is paramount.
Further complicating the issue of specificity of indicators is the difficulty adolescents have in reporting their parents' education and occupation.
During evolution, as new signaling pathways emerged from the duplication and divergence of pre-exiting parts, the issue of specificity must have been paramount.
