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However, they all face the issues of side effect, high toxicity, ineffective in chronic phase and drug resistance [ 116].
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But the issue of side effects is not settled.
Despite the massive global spend on biology-driven drug discovery, tackling the issue of side effects and adverse events resulting from drug promiscuity represents a persistent challenge.
We will return to the issue of side constraints after the discussion of the next argument.
Interestingly, this issue of side effects with ARV drugs was also an important aspect of adherence studies in developed countries.
Moreover, this review does not discuss the issue of side effects and clinical efficacy of celecoxib, but focuses on its potential tissue structure-modifying, mostly chondroprotective, effects.
Given the equal effectiveness of current regimens, the selection of therapy for an individual patient is mainly based on the issue of side effects and the ease of administration in a given setting.
It was commonly reported that the issue of side effects was never discussed – not only at the time the prescription was written but also even when the patients tried to ask about it.
Although our programme of human factors training was triggered by the issue of side errors, the subject's scope is far wider than that with much greater potential benefits in terms of patient safety, staff satisfaction, staff stress and work efficiency.
Our findings echo those from an interview study with 27 women most of whom were considering tamoxifen in a primary care setting, where the issue of side effects and the association with 'chemotherapy' were identified as barriers to uptake (Heisey et al, 2006).
Beyond the deal with Jordan, the United States has made labor and environmental issues part of side agreements in some trade pacts, and is experimenting with innovative arrangements with developing nations like Cambodia.
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