Sentence examples for issues of sequence from inspiring English sources
To address the issues of sequence order independence and evolutionary conservation, we encode amino-acid residues in the ligand-binding site as an undirected graph.
Manual annotation is well suited to interpreting issues of sequence quality that can compromise the ability of many computational gene builders to utilize ESTs, extracting useful information from them using alignment visualisation tools such as Blixem and Dotter (22, Barson,G. and Griffiths,E., manuscript in preparation).
As highlighted by restraints in the present study, issues of sequencing depth, sample size and unbiased data generation are of foremost importance.
Therefore, we proposed to sequence a separate virulent isolate of F. tularensis subsp. tularensis A1 and compare it with Schu S4 to evaluate the issue of sequence divergence over time.
However, it will be important to take into account this issue of sequence complementarity between sense and antisense tRNAs when exploring other antisense tRNA properties.
Author's response : The issue of sequence redundancy was dealt with in two ways: First, nearly identical sequences (as well as sequence fragments) were removed; this pruned the input alignment from ~259,000 down to ~65,000 sequences.
Addressing the issue of sequence conservation at imprinted loci, we have compared genomic sequences and highly conserved elements of imprinted genes to those of all autosomal genes in the human and mouse genomes.
TileQC also plots genomic alignment results based on number of mismatches on individual tiles and such graphs are very helpful for understanding the impact of quality issues on sequence alignment.
This approach is particularly useful for identifying quality issues in a small number of sequence reads related to rare genome structure changes or transcriptome variants, as it is hard to judge the randomness of distribution for a small number of sequence reads.
But consider also that the losers in the DOMA case -- namely John Boehner and his House Republicans, who hired famed advocate Paul Clement to defend the law after the Obama administration refused to do so -- still hold a few cards on the issue of sequencing.
