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ROC AUC is constant across prevalence of abnormality [ 3] and authors argue that issues of prevalence and misclassifications costs (see Section 2 below) should only be considered once the "intrinsic" performance of a test is known [ 10].
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Prospective collection of multicentric data of contemporary patients may clarify the important issue of prevalence.
The issue of prevalence with other brain areas is a more difficult issue to deal with in the limited space we have available, but we do agree that it is an important issue (especially for theoretical model-building reasons).
Another study, which addressed the issue of prevalence of P. aeruginosa pneumonia in rats colonized by C. albicans, evaluated the quantitative bacterial cultures of P. aeruginosa in rat lungs at 48 h post-infection [ 16].
The issue of prevalence is not marginal: we have found that compared with subjects without diabetes who were referred for 24-h ambulatory BP monitoring, those treated for diabetes were less likely to have WCH (and more likely to have masked hypertension) (1).
Validation of a marker for use in a population requires attention to issues of background prevalence, sample size, natural history, persistence, variability, confounding factors, and predictive value.
Perhaps the most obvious is the need to explain and convince with regard to the issue of multiple prevalence rates rather than a single prevalence rate for disability, which is still often sought.
On "Costas Tonight," his talk show on the NBC Sports Network, to be telecast Thursday night, Mr. Costas again thrashed out the issue of the prevalence of guns in American society, this time with two guests, the former basketball star Charles Barkley and the former tennis champion John McEnroe.
Prospective, larger and multicentre data collection may clarify further the important issue of LMS prevalence.
Concern might also be expressed that the vast majority of studies included in this analysis, including all prospective studies and randomized controlled trials, were not designed to address the issue of leiomyosarcoma prevalence in such surgeries.
Then, we considered the effectiveness of the legal responses to the issue of FGM prevalence in that country.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com