However, the issue of high-dose insulin therapy has not been properly studied, and such people nearly always have high endogenous insulin secretion and some tendency to an enhanced inflammatory state, putting them at risk.
Treatments, like the consumption of high doses of mercury, were harsh, dangerous and only minimally effective.
However, because of palatability issues at high doses, four of five female volunteers stopped supplementation earlier than planned; two at week 6 and two at week 7.
The issue is made more complex by the potential role of high-dose step-down steroid therapy used in combination studies (discussed later).
This study addressed two important issues for the management of first-line chemotherapy in ovarian cancer patients: the impact of high-dose therapy and the role of cyclophosphamide.
Data were unavailable on over-the-counter purchases of high-dose aspirin and low-dose ibuprofen dosing schedules.
The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1472-6882/11/72/prepub A preceding survey on the issue of immunosuppression through high dose VAE was funded by Weleda, Wala, Helixor and Novipharm.
Table 5 shows the ability of the ePMR systems to highlight drug-allergy issues, contraindications, inappropriate doses, drug-route suitability, issues with high-dose initiation of medicines and significant dose increase assessment.
Occasionally, for those with long-standing pain issues who require unusually high doses of medication, an intravenous drip can deliver a steady supply, which can be controlled by the patient with a button (within limits) or by a nurse or caregiver.
