However, their use is frequently beset by serious complications relating to device-associated infection and microbial biofilm formation, as well as issues of patient discomfort and acceptability.
Although recent enhancements in needle design, such as microtapering and bevel changes, have helped to address some issues of patient discomfort, fear and negative perceptions of injectable therapy remain.
To increase the patient acceptance for wide-spread application of CTC cancer screening the issue of patient discomfort by bowel preparation and radiation exposure needs to be addressed further.
These are not issues of perception or discomfort, but of simple economics.
Mitt Romney has a more ambivalent relationship to religion as a wedge issue, given the level of discomfort that many American have toward Mormonism.
For Mr. Giuliani, a Brooklyn-born Roman Catholic who once considered entering the priesthood, the issue has been a source of discomfort throughout his political career, especially during his first bid for mayor of New York nearly two decades ago.
The diagnostic label is "a huge barrier and a challenge of great magnitude," said Sarvis, who chose his words carefully in an interview that reflected a level of discomfort about transgender issues that other gays -- including participants at OutServe -- rarely acknowledge outside their community.
Yet, despite the radically inclusive outlook these Japanese designers espoused, the wider fashion industry's discomfort around issues of age and body shape continues to warrant discussion – and it's clear it still has a lot to learn from them.
"It is one of the bigger issues, this discomfort around the school board making all these drastic changes.
A first issue to be considered is which degree of discomfort can be attributed to the high punctual luminance values found in the type II LEDs studied signals.
