Similar to many registration clinical trials facing limited resource issues, functional impairment was measured by the SDS as one of the secondary endpoints, and our clinical trial did not employ additional informant assessment such as clinician-reported measures of functioning or performance-based assessments to validate the self-reported functioning outcomes.
Beyond technical issues, functional HER2 protein up-regulation on CTCs cannot be excluded, and the acquisition of HER2 amplification during the course of the disease has been suggested [ 74].
As a major public health issue, functional constipation negatively affects health-related quality of life and is associated with substantial costs.
In part to address this issue, functional imaging is increasingly used to assess clinical response, and especially to provide information on the development of new therapies[ 43 ].
It may therefore be the case that DISC1 provides an indication of biological pathways that are central to mental health issues and functional studies have shown that it functions in multiple signalling pathways.
To describe longitudinal change in perceived health, presence of health issues, and functional level in adults with cerebral palsy (CP).
The additive manufacturing is a viable technology in solving the design issues of functional parts made of Ni-Mn-Ga magnetic shape-memory alloys (MSMA).
In this lab study, with regard to the technical and executive issues, common functional performance-based tests of bitumen were performed on specimens through adding Gilsonite with 0, 2, 4, 6, 8, 10 wt.% of made bitumen specimens.
With the development of electronic equipment toward high accuracy, high density, high frequency and atrocious service environment, the electromechanical coupling issues of functional surface will be more prominent, such as the passive intermodulation and the heat transfer problem, etc.
Managing minimally displaced fractures of the scaphoid waist in young patients employed in physically demanding work is even more challenging due to the issues of functional limitations and time off work.
Prior to re-design, the evaluation identified issues with functional design, task design, visual ergonomics, and tractability for the End-user, which meant that the simulator was unfit for purpose.
