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Finally we recorded whether Conclusions sections contained statements concerning methodological issues, efficacy, or safety/toxicity.
Numerical results presented in the Results sections were classified as relating to methodological issues, efficacy, or safety/toxicity.
Practitioners should provide evidence-based information on safety issues, efficacy, and potential interactions among commonly used CAM treatments – instead of brushing the topic aside or ignoring its usage.
In the Discussion sections we again rated coverage of methodological issues, efficacy, and safety/toxicity as none, minimal, substantial, or the major focus of the section.
Formulating a view on the relative merits of aromatase inhibitors (AIs) and tamoxifen requires an examination of the available evidence regarding four major issues – efficacy, toxicity, tolerability/quality of life and cost.
We examine stated objectives, results and conclusions drawn, and in particular whether these relate to methodological issues, efficacy or safety/toxicity: comparisons are drawn between papers reporting drug and non-drug trials.
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Randomized, controlled clinical trials are sorely needed to resolve issues of efficacy.
In addition to issues regarding efficacy and potential side effects of triptans, other factors may affect patients' ability or willingness to treat early.
The underutilization of preventive drugs has several explanations ranging from drug-associated issues (limited efficacy, poor tolerability profile) to education of practitioners, pharmacists and patients, and it also involve the limited access to qualified care.
This paper describes the development of an after-school program for middle-school students that simultaneously addressed issues of efficacy and effectiveness in an effort to create an evidence-based intervention (EBI) that can be implemented in school settings.
The issues of efficacy vs. safety in these populations are separate considerations.
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