1240-48), Bacon had confronted and reviewed some of the major issues concerning the Latin Averroism which eventually produced a major crisis at Paris in the period 1266 77.[2] And, as we will see below, Bacon, in his works from the 1260s, will revisit these topics.
The present review is an attempt to classify the major issues concerning the neuroprotective properties of citicoline into three categories: facts, i.e. those that are solved with an acceptable degree of certainty; doubts, i.e. those that are likely misinterpreted; and unresolved issues, i.e. those that remain unexplained.
Our data indicate some major issues concerning the specificity, the appropriate control and the dose of Nec-1 and its derivatives, and may have major implications for the use in experimental disease models and the interpretation of the published data.
One of the major unresolved issues concerning the genetic architecture of abiotic stress response is whether functional variation arises from variation in core signaling components, such as transcription factor, kinases and phosphatases, or these variations are confined to effector genes, such as biosynthetic enzymes, redox regulators and heat shock proteins [ 63].
Major issues concerning the design of the system stem from operation duty cycle of 1000 s ON/5000 s OFF.
To this end a questionnaire survey was conducted together with regular consultations with the common's board and staff to discuss shareholder participation and other major issues concerning the common.
This "Changing Earth Science Network" focuses on the exploitation of Earth Observation (EO) data to address major issues concerning the broader context of climate change in five scientific research domains: the oceans, atmosphere, cryosphere, land and solid earth.
Major issues concerning the pharmacology including the efficacy/safety of DOACs in clinical trials on prevention and treatment of thromboembolism (in medical and surgical patients), as well as in AF have been recently reviewed (139).
Regrettably three major issues concerning the included studies; 1) small study size, 2) clinical heterogeneity and 3) poor methodological design, restrained us to present a comprehensive statistical analysis with pooled data. 1) Small study size: 9 out of the 17 included studies included < 20 patients [ 17- 19, 25, 28, 29, 34, 35].
Here we report only major clinical issues concerning the management of advanced non-small-cell lung cancer (NSCLC).
