Long judgments are often difficult to distil into media-friendly nuggets and complex legal issues are over-simplified or misrepresented, particularly, it must be said, in the press.
Considerable waste can occur if costly RCTs need to be discontinued because assumptions about recruitment or other feasibility issues were over-optimistic [ 28].
"This issue is over and done with.
"The issue is over, done, it's history".
It's almost as if the film is saying … the Iraq issue is over, and the nice guys won.
"Look, the teachers have worked out a plan to pay the money back, the issue is over," he said.
"This war has brought Iran and Hamas back together, and the debate over the Syrian issue is over," said Hamid-Reza Taraghi, who heads the international department of the influential Islamic Coalition Party.
The executive director of the New York League of Conservation Voters, Marcia Bystryn, said in an interview that the time for confrontation on those issues is over.
Nor will Arizona's border and immigration issues be over.
During the last year of negotiations, one of the thorniest issues was over patent lengths for certain complex drugs known as biologics.
