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The high-dimensional nature of the data from which a new signature is derived raises challenging issues and necessitates the modification of classical methods to adapt them to this framework.
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Although technological solutions are allowing biobanks to reach new levels of integration, increasingly powerful data-collection tools, analytical techniques, and the results they generate raise new ethical and legal issues and challenges, necessitating a reconsideration of previous policies, practices, and ethical norms.
The most salient characteristics of landscape ecology are its unequivocal emphasis on the relationship among pattern, process, and scale and its focus on broad-scale ecological and environmental issues that necessitates the coupling between biophysical and socioeconomic processes.
The #NewFIFANow campaign established in January 2015 is one example of how creative campaigning, and the effective use of social media can apply pressure to stakeholders (in this case, sponsors and national soccer associations) and go a long way in helping to shine a light on issues of concern and necessitate remedial action.
Conclusions: Although the intervention increased completion of HPV vaccinations, uptake remained lower than the national target, which, in addition to cost effectiveness and acceptability issues, necessitates consideration of other ways of achieving it.
Moreover, some complex issues and futures of species may necessitate a more complicated debate and resolution.
Given his early travails, including season-ending knee and ankle problems and painful groin issues that necessitated pre-game shots for most of his career, it's remarkable that he actually lasted as long as he did.
(Nuffield Council on Bioethics 2012, xx) Creating citizens who are able and willing to be actively involved in a range of health topics necessitates helping them work through a variety of issues and doing this from different perspectives.
However, the next pandemic may be crueler: it may cause more serious morbidity and mortality, last longer, and necessitate the issuing of a range of recommendations over time to guide public action.
Exploring these issues necessitates a wider range of research questions that speak more directly to the contextual specificity of the EBPH process in particular settings (Rychetnik et al. 2012).
The above-described findings raised a number of issues that necessitate further investigation, as discussed below.
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CEO of Professional Science Editing for Scientists @ prosciediting.com