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We argue that regulators will have to accept some of the limitations surrounding the issue of validation, which may seem radical.
The two most quoted arguments against an in vitro testing battery are concerns about the relevance of any observed effects and the issue of validation.
The key issue of validation of genomic mutations was explored through cross-platform comparison of results obtained from two NGS technologies as well as a mass spectrometry-based method.
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That's our problem, how to make issues of validation sexy.
Overall, the transgenic models performed well, but important issues of validation and standardization need further attention to permit their regulatory acceptance and use in human risk assessment.
In an attempt to tackle the issues of validation, two phase II multicentre national trials are underway - Neo-COMICE in the United Kingdom and I-SPY 2 in the US, both of which are examining the effectiveness of MRI in the early prediction of response to neoadjuvant chemotherapy and the development of surrogate imaging biomarkers.
The discussion elaborates on the issue of model validation, both in terms of the BN and in light of the adopted uncertainty/bias-based risk perspective.
I initially wanted to ask her about the specifics of its development, but naturally we started talking about the broader issue of craving validation.
I share your frustration with the issue of antibody validation.
In this section we explore the issue of experimental validation of our model.
The review by Wardle and Tan provides a clear and accessible treatment of the issue of antibody validation for chromatin immunoprecipitation (ChIP).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com