Freedberg first noted 7-fold elevated translation in psoriasis lesions and later suggested that such hyper-translation might be "a very central issue to the solution of the pathogenesis of psoriasis" [ 75].
At a time when Europe is struggling with soaring unemployment and the enduring euro crisis has raised existential concerns about the 28-nation bloc, there is scant debate in Brussels over the critical issue of whether the solution to the Union's problems lies in "more Europe" — meaning greater political and economic integration — or less.
Our discussion considers computational efficiency, scalability, and some implementation issues of the solution methods.
But the key issue of this solution of violence and criminality, crime in Mexico and a lot of countries in Latin America, is building a state that's able to enforce law.
Fluid resuscitation is one of the cornerstones of the treatment of patients in the intensive care unit, particularly for the prevention and management of acute kidney injury [ 44], and safety issues of the solutions used therefore assume major importance.
Another issue pertains to the solution of McKinsey paradox.
In the case of Spitzer and the investment banks' conflict-of-interest issue, the solution could simply focus on better disclosures concerning which reports written by the analysts involve companies that are the bank's clients.
For this proposal a comparative assessment was done to identify the main issues of this solution.
Security, availability and efficiency issues of the proposed solution are described.
Herein, two specific types of problems, having traction free boundaries, are examined and the issues related to the solution of them are addressed.
Nuclear waste disposal is a significant technological issue, and the solution of this problem (or lack thereof) will ultimately determine whether nuclear energy is deemed environmentally friendly, despite significantly lower carbon emissions than fossil fuel energy sources.
