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The climate is the central development issue of the next century.
Member states' ambassadors have not broached the issue of the next secretary general.
Dealing with this disconnect will be the central economic issue of the next decade, in Europe, Japan and this country.
"A major civil liberties issue of the next decade will be the control and expansion of consciousness," they declared.
The gap between the property haves and have-nots has never been starker, and housing is set to be a defining issue of the next general election.
Tony Willis Sutton Coldfield, West Midlands Jackie Ashley speculates that Ed Miliband might be right that the NHS could become the defining issue of the next election.
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This is one of the core issues of the next election and it needs to be much better articulated by the opposition parties.
The challenge remains to turn more of the latter into the former, one of the big industry issues of the next 12 months and beyond.
Given that taxes are likely to be one of the big political issues of the next few years — and maybe the biggest one — it's worth understanding who really pays what in taxes.
In truth, the defining issues of the next 100 years cannot yet be defined, any more than for the 20th century they could securely have been outlined in 1900.
Actively cooled Plasma Facing Components (PFCs) are one of the major issues of the next generation Tokamaks.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com