"Enough is enough," Sam Warburton had declared beforehand, addressing the thorny issue of Wales' inability to beat one of the southern hemisphere's big three over the past four years.
Napoleon's final defeat at Waterloo on June 16 18, 1815, was again decided upon the issue of his inability to surprise and to prevent the joining up of two armies invading France along separate lines, in this case Wellington's Dutch and English troops and Gebhard Leberecht von Blücher's Prussians.
But this creates a lot of difficulties and one such issue is the inability to collaborate effectively.
Perhaps the biggest issue: the inability of younger generations to support the health care and retirement needs of a ballooning older population.
An emerging issue relates to the inability of sodium bisulfite conversion, which is the commonly used method for determination of 5-mC at single-base resolution, to distinguish 5-mC from its oxidative derivative 5-hydroxymethylcytosine (5-hmC) [ 131].
Glazer wrote that a "combination of off-field issues and the inability to form a strong bond with either of Miami's past two starting quarterbacks (Matt Moore and Chad Henne) put a damper" on some of his success.
The poll found that the edge held by the Democrats this year on the issue had diminished, perhaps because of the inability of the party's leadership in Congress to push through measures that would restrain Mr. Bush or mandate any steps toward ending the war.
While IMVU may have solved the problem of black market trading, there is still the issue of inflation and the inability to regulate RMT transactions.
Beyond methodological issues, the inability of comprehending the value of BRCA1, ERCC1, RRM1, and TYMS (B, E, R, T) expression in the assessment of NSCLC patients may be related to the nature of these markers.
Some workers raised the issue of inability to read signs - in Spanish -- as a potential problem.
