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The issue of strain selection is only a question of which rodent model to use when very little or no toxicity data are available for a substance.
Since each Drosophila lab has their own wild type (usually Canton-S) isolate, this issue of strain differences is actually a very important one for between lab reproducibility.
Long-term epidemiological studies incorporating genotyping will be needed in order to investigate the issue of strain introduction and/or transient infection cycles.
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The NTP held a workshop in June 2006 specifically to address the issue of rodent strain and stock selections (NTP 2005a).
To address potential issues of strain-to-strain variation, the graS and imp transposon insertions were transduced into a CA-MRSA isolate called LAC* (erythromycin sensitive variant of LAC, see Materials and Methods).
These include the expression of the siRNAs in tissues; DNA copy number of the transgene; the virus titers/viremia from plasma and perhaps in nasal secretions; and issues of strains of virus.
In this regard, the issue of prion strain selection or mutation will be a major factor.
However, the method has been criticized for issues including insufficient number of strains, not controlling for false discoveries, the complex haplotype structure of inbred mice, and failing to account for genotypic and phenotypic subgroups.
Antifungal drug resistance is fast becoming a serious issue due to the emergence of strains resistant to currently available antifungal agents.
The print version of the story, which covers 72 pages in a special issue of Bloomberg Businessweek, strains the definition of "article". It's really a short book about computing, computers and culture, and an excellent one at that.
To investigate this issue, 417 days of strain data acquired from the long-term structural health monitoring system of Taiping Lake Bridge in China are employed in this paper.
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