Sentence examples for issue of specificity of from inspiring English sources

Further complicating the issue of specificity of indicators is the difficulty adolescents have in reporting their parents' education and occupation.

Finally, we considered the issue of specificity of association by investigating the effects of tobacco use on the same educational outcomes.

Thus, the issue of lack of specificity of fractionated plasma metanephrine measurements is applicable primarily to non-genetically predisposed individuals in whom sporadic pheochromocytoma is sought.

Beyond the fundamental issue of sensitivity is that of specificity of the localizing information obtained, the evaluation of which remains a challenge due to the dubious quality of the so-called gold standard of localization in many patients and fundamental study design issues [ 10 ▪].

A number of reports have raised the issue of specificity and efficiency of gene transfer [ 3, 4], specifically to neoplastic cells.

Together, these issues revolve around the lack of specificity of these techniques despite high sensitivity for detection of bone metabolism, which may not be associated with oncological phenomenon.

During evolution, as new signaling pathways emerged from the duplication and divergence of pre-exiting parts, the issue of specificity must have been paramount.

For genome-editing techniques, the issue of specificity and delivery is paramount.

Lack of specificity of these indicators limits their use in medicolegal issues.

Thus, we were unable to ascertain whether phospho-SMAD expression is intact or diminished in Megf8 null embryos (which would imply that Megf8 modifies BMP4 signaling via a non-SMAD dependent mechanism), or if we could not observe a difference that was present because of issues of specificity or because this assay would not allow us to detect subtle changes in phospho-SMAD levels.

More broadly this paper highlights the issue of epitope specificity of monoclonal antibodies directed against disease-associated markers, specifically when they are glycoproteins.