After the description of the experimental setup, the fundamental issue of signal processing and data analysis are discussed in detail.
Three recent papers, including one by Sun et al.1 in this issue of Signal Transduction and Targeted Therapy, analyze the structural basis of the inhibition of retromer function by the Chlamydial effector protein IncE.
One feasible solution to the issue of signal compatibility is to design a spectrum-efficient modulation signal that has better navigation performance and backward compatibility with adjacent signals and services in operation.
This review would be incomplete without considering the issue of signalling bias by these receptors.
The issue of signal specificity in Boolean networks has also been addressed by the recently published mechanistic Boolean approach [ 10], which relies on specific state based description with the associated scaling issues due to the combinatorial complexity (reviewed in [ 8]).
During the Clinton Administration, he began writing letters to the President on foreign-policy issues of signal importance.
Issues of signaling specificity feature prominently in mitogen-activated protein kinase (MAPK) cascade-mediated signaling [ 10- 16].
Our approach combines three statistical tests that deal with issues of signal-to-noise levels that are often problematic when searching promoters with collections of known PWMs.
The fact that it is the first time in the history of India when people were out on the streets on the issue of gender signals an important paradigm shift on national discourse of sex, sexuality and rights of women.
Furthermore, taking into account the fact that some transcription factors form a dimer or even more complex structures, and transcription process can sometimes involve multiple factors with variable spacers in between, we extend the original problem to an even more challenging one by addressing the issue of combinatorial signals with gaps of variable lengths.
As social systems cannot observe themselves from the outside, the issue of weak signals should be explained as the outcome of a self-referential dynamics that finally leads to the paradox of knowing the unknown.
