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Therefore, we proposed to sequence a separate virulent isolate of F. tularensis subsp. tularensis A1 and compare it with Schu S4 to evaluate the issue of sequence divergence over time.
However, it will be important to take into account this issue of sequence complementarity between sense and antisense tRNAs when exploring other antisense tRNA properties.
Author's response : The issue of sequence redundancy was dealt with in two ways: First, nearly identical sequences (as well as sequence fragments) were removed; this pruned the input alignment from ~259,000 down to ~65,000 sequences.
Addressing the issue of sequence conservation at imprinted loci, we have compared genomic sequences and highly conserved elements of imprinted genes to those of all autosomal genes in the human and mouse genomes.
Similar(56)
There are some principles, but we have to decide the whole issue of sequencing".
But consider also that the losers in the DOMA case -- namely John Boehner and his House Republicans, who hired famed advocate Paul Clement to defend the law after the Obama administration refused to do so -- still hold a few cards on the issue of sequencing.
This issue of sequencing error in 2× genomes is our focus in this article.
In this article, we have examined the issue of sequencing error with respect to twenty newly available low-coverage (2×) mammalian genome assemblies.
To address the issue of sequencing depth, we performed additional data analysis using the first 7 million sequencing reads of 010_M and 221_M data (Additional file 1: Table 4&5).
To address the issues of sequence order independence and evolutionary conservation, we encode amino-acid residues in the ligand-binding site as an undirected graph.
Manual annotation is well suited to interpreting issues of sequence quality that can compromise the ability of many computational gene builders to utilize ESTs, extracting useful information from them using alignment visualisation tools such as Blixem and Dotter (22, Barson,G. and Griffiths,E., manuscript in preparation).
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