Sentence examples for issue of selectivity from inspiring English sources

One concern with the design of Nrf2 activators that are electrophilic covalent modifiers of Keap1 is the issue of selectivity.

The key problem many probes encounter is the issue of selectivity, since 23 human MMPs, despite playing different physiological roles, have structurally similar active sites.

We are acutely aware of the issue of selectivity of drug action for inhibitors targeting the MtbPRPPase, as the mycobacterial enzyme shares a significant degree of sequence identity with human counterpart (sequence identity of 44%).

This work does not address the issue of "selectivity" because only the heart was examined.

These authors discussed the result as an issue of selectivity; however, the agonistic and antagonistic properties of the ligands used may just as much contribute to the differences.

In contrast, when using procedures, such as immunostaining and flow cytometry, it is crucial to address the issue of selectivity [ 18- 20].

Five different routes address the major issues of selectivity to afford the cis product in isomerically pure form and in high yield.

In order to investigate issues of selectivity and specificity in protein ligand interactions, we have undertaken the reconstruction of the binding pocket of human factor Xa in the structurally related rat trypsin by site-directed mutagenesis.

Fusion of Frizzled8-cysteine rich domain (binds Wnt) to the human Fc domain inhibited Wnt signaling and teratocarcinoma growth in mice but has not been widely used in vivo possibly due to its low in vivo efficacy or issues of selectivity [42].

However, issues of selectivity over host kinases are neither resolved nor predictable.

We are in the process of obtaining the data that would allow us to diagnose and directly address any issues of selectivity bias.