Sentence examples for issue of mixture effects from inspiring English sources

In this article, we review experimental studies that address the issue of mixture effects at low doses, for both similarly and dissimilarly acting chemicals.

The question arises whether these technical issues influence the outcomes of mixture studies, especially when they are aiming to investigate the predictability of mixture effects.

A second issue of relevance to regulatory toxicology concerns the question of mixture effects at low doses.

The assessment of mixture effects of estrogenic agents is regarded as an issue of high priority by many governmental agencies and expert decision-making bodies all over the world.

The concentration response to the mixture was then determined and related to the effects predicted by CA. In order to directly relate the effects of the compounds to the observed mixture effects, we performed a second mixture experiment.

It is interesting to note that not the purported intrinsic conservativeness of safety factors, but the complexity of the issue and a lack of data were chosen as justifications for discounting mixture effects.

We compared the observed mixture effects against component-based mixture effect predictions derived from additivity expectations (assumption of non-interaction).

Scientists agree that one of the major challenges is to address the issue of mixtures.

The chapter is designed to address issues of experiment design of mixture studies; summarize the available literature on organophosphate (OP) pesticide mixtures, carbamate (CM) pesticide mixtures, and mixtures of OP and CM pesticides; and address future research priorities.

Step 5: Estimate joint effects of mixtures: We then estimated the joint effects of these C&RT-generated mixtures using the base model with indicators for each mixture.

Different issues related to the numerical estimation of mixture models are also discussed.