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The issue of concordance [21] or lack thereof [17], [22] between different prognostic signatures was also debated.
The resulting 111,760 phylogenies and 22,352 alignments have been deposited in PhylomeDB [12] (http://www.phylomedb.org; phylome codes SceP60, SceP21, SceP12a and SceP12b) Some methodologies have been previously proposed to explicitly address the issue of concordance between species trees and individual gene trees [13], [14].
The issue of concordance of HER2 status between primary tumour and metastasis has been scarcely addressed in the scientific literature.
One group had addressed the issue of concordance, when they compared Affymetrix data with Real time quantitative data for 48 genes.
While correlation between apoB and non-HDL-C is reckoned very high, the issue of concordance, agreement and equivalence of use for predicting risk in diabetic patients remains controversial [ 3- 5].
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Recently, several studies addressed the issue of HER2 concordance between primary carcinoma and its metastases.
Lay educators recruited from the community bring a number of skills, particularly knowledge of health beliefs and practices, yet, for participants attending self-management interventions, skills such as empathy, understanding, and providing health information bypassed issues of ethnic concordance.
This reflects recent thinking about the importance of shared decision making about medication by service users and clinicians [ 53, 54], ongoing debates around issues of treatment concordance and adherence [ 51, 55], as well as research that links therapeutic relationship with medication adherence [ 56].
To date, only one study has addressed this issue showing a high level of concordance between HER2 status evaluated on primary tumours and regional lymph node metastases by means of both immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH; Marx et al, 2009).
Nevertheless, given the inherent issues of dissection, the degree of concordance provides substantial evidence that the software method represents an appropriate non-invasive means to determine tissue mass.
Beyond our hypothesis, we found that chronic disease management issues specific to women tended to have lower rates of concordance than other aspects of care.
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