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Of course, the issue of batch effects when combining data from multiple microarray experiments conducted in different laboratories must be considered carefully.
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We also describe control procedures to address the issue of batch-to-batch variability in animal diets.
To exclude issues of batch dependence or dose dependence of the inhibitor used, we also did a dose escalation study raising the inhibitor concentration from 10to2525 μM and tested PS-1145 from a different provider (Supplementary Figure 2A), confirming our initial results.
The coaxial turbulent jet mixer can overcome the issues of batch-to-batch reproducibility that are often a considerable challenge for scale-up of NP synthesis from the laboratory to clinical and industrial production.
Then there was the issue of a batch of minerals contaminating Dasani with a possibly carcinogenic bromate.
Think Progress reported Tuesday that a White House spokesman was disputing the notion that President George Bush would not issue a "batch of pardons" at the last minute.
In today's White House press briefing, a reporter noted to spokesman Tony Fratto that the "administration has indicated that the president is unlikely, at the last minute, to issue a batch of pardons".
Convergence analysis of iterative identification-optimization schemes is a key issue in modeling for optimization of batch processes.
Inherent process and measurement uncertainty has posed a challenging issue on soft sensor development of batch bioprocesses.
Also considered is the issue of operating the next batch with a suboptimal policy that is at a fraction of the distance between the previous policy and the calculated optimal one, so that the uncertainty of the new policy is reduced to an acceptable level.
However, past studies have shown many concerning issues in regard to the use of batch process such as high residence time, product inconsistencies across batches, high labor cost and difficulty in industrial scale up.
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