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In the FFP-based comparison, the most critical issue is determination of the length of the k-mer, which is selected based on three criteria: (1) FFP's reconstruction capability of whole genome or proteome from FFP, (2) tree convergence, and (3) statistical reliability support.
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The proposed model allows to analyze the effects of the specialist's interventions on the short term dynamics of bid/ask prices and address a relevant market design issue, that is determination and analysis of the optimal endogenous upper bound that – according to economic conditions – should be imposed by Stock Exchange on the quoted bid/ask spread.
At this point, a critical issue is the determination of three-way decisions.
When there is no dispute as to the charged violation, the sole issue is the determination of the appropriate sanction.
Actually, if fracture simulations are considered, the essential issue is the determination of the tensile strength (and stress-strain behavior) dependencies (see Figure 13).
For this reason, the key issue is the determination of a well-defined threshold in order to separate converging and oscillating signals.
During the separation of signal and noise, a critical issue is the determination for the dimensions of the block Hankel matrix which is built from noisy measurement data.
Thereby an important issue is the determination of the biological effectiveness of photon radiation as a function of photon energy by using low-energetic, monochromatic channeling radiation (10 100 keV) and high-energetic bremsstrahlung (up to 40 MV).
A directly related issue is the determination of the proportionality coefficient in the linear flame speed-flame stretch relation of weakly-stretched flames, known as the Markstein length, which depends strongly on the location inside the flame zone where it is measured or calculated.
[ 7] The key issue is the determination of the doses at which methylmercury is neurotoxic.
A key issue is the determination of the performances of a given setup, in terms of spatial resolution (location of fluorescent sources) and signal quantification (fluorophore concentration).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com