Sentence examples for issue in understanding of the from inspiring English sources

A key issue in understanding of the Alzheimer's disease (AD) is the recognition of relations between clinical characteristics of patients and their biological properties that can be objectively measured.

Their importance for historians is that they provide an index of Panhellenist, conservative Greek opinion, and whoever reads with attention the "Panegyric" (380), "On Peace" (355), "On the Areopagus" (354?), "To Philip" (346), and the "Panathenaic" oration (begun 342, completed 339) will have gained considerably in understanding of the larger issues of the age.

A central issue in understanding the role of TGF-β1 in the progression of epithelial cancers is the elucidation of the mechanisms underlying the signalling cascades.

The relationship between these two means of information transfer remains an unresolved but key issue in our understanding of the primary and secondary network changes underlying Parkinson's disease.

Thus 'subjective functioning' or 'self-perceived functional status', i.e. a person's evaluation about its functional abilities, is a key issue in our understanding of the path from early symptomatology to disability and plays an important role in the decision making process that leads to the use of health services.

The characterization of metabolic flux profile in living cells is an important issue in understanding the regulation of normal metabolism and the development of disease processes.

The identification of kinetic pathways has become a central issue in understanding the nature of binding.

A major issue in understanding the aetiology of ES/PNET is understanding how EWS/FLI-1 activates the many genes shown to be increased.

A central issue in understanding the characteristics of telomeres in ALT tumours is to distinguish the properties that arise from the ALT mechanism versus elongated telomeres per se.

An important issue in understanding the complexity of COPD as an illness and thereby its management, is what determines the subjective health status of these patients.

How these events lead to Smo activation remains a central unresolved issue in understanding the molecular mechanisms of Hh signaling.