Through in silico modeling and keratin filament assessment of genetically engineered HaCaT cells, Natsuga et al., as reported in this issue, have demonstrated how changes in charge and structure of a replacement amino acid in keratin 14 can cause disease (KRT14pA413P, EB simplex) or no clinical effect (KRT14pA413T, polymorphism).
"I do however think some of the issues have demonstrated some of the problems with the model that is now in place, particularly the problems they have had in dealing with crises as they arose".
It is remarkable that she has used her position as the First Lady of Kenya to tackle a critical human development issue and has demonstrated extraordinary initiative, integrity and courage to save the lives of women and children.
On social issues, he has demonstrated that you don't have to be a Bible-thumping pro-lifer to attract the vote of evangelicals.
19 PEGPH20, a PEGylated human recombinant PH20 hyaluronidase, surmounts these issues and has demonstrated comparable activity in vivo, inducing rapid perfusion increase in xenograft tumours.
While the current study did not address the issues of normalization, it has demonstrated that data from the two different technologies, if properly filtered, will yield comparable results.
But even as the mayor has shown courage on that issue, time and again Bloomberg has demonstrated that his primary loyalty is to Wall Street.
Apart from the issue of hepatotoxicity, soluble TRAIL has demonstrated a potent antitumour activity against a wide range of tumours both in vitro and in vivo (Pitti et al, 1996; Nimmanapalli et al, 2001; Rohn et al, 2001; Naka et al, 2002).
As the recent controversy over paying for social care has demonstrated, few issues provoke as much anger as the suggestion that elderly homeowners should be required to sell up and move to somewhere smaller and cheaper.
