Here we address and clarify these issues: Evidence for the absence of bacteria in the supernatant and how it was performed is now elaborated in the methods section of the revised manuscript.
Although there has been some basic success in analysing the role of clock genes in sleep (Franken, this issue), compelling evidence for a contribution of clock gene dysfunction to neurodegenerative diseases and sleep disorders is lacking [ 26 28].
Similar assessments of other taxonomic groups in this issue provide evidence for widespread plastic and adaptive responses to climate variation and concurrently highlight the same lack of data for evolutionary responses (Franks et al. 2014; Reusch 2014; Schilthuizen and Kellermann 2014).
He points to Mr. Gandhi's ineffective public speaking, unremarkable career in parliament, inability to lead the Congress to victory in regional elections and lack of engagement with contemporary issues as evidence for this argument.
Our work addresses both of these issues, providing evidence for a mechanism in which the C-terminal motif in Brca2 helps time mitotic entry by controlling the dissolution of DNA-bound Rad51 assemblies.
This article addresses four issues: 1) evidence for genotoxicity with thiazolidinediones; 2) our knowledge about increased fracture rates; 3) the fluid retention, macular edema, heart failure issue; and 4) CV safety, in particular, in regard to myocardial infarction (MI) for rosiglitazone.
To address these issues evidence is needed on factors responsible for poor treatment outcomes (e.g. patient compliance to treatment, performance of monitoring and self-management, etc).
For hepatocarcinogenesis, a key issue was whether evidence for peroxisome proliferation is sufficient to establish the peroxisome proliferator-activated receptor α (PPARα)–activation mode of action.
Threlfall et al in this issue present direct evidence, for the first time, that the UK breast screening programme (NHSBSP) is reducing breast cancer mortality.
We hope it will attract maternal policy-makers' more attention on this issue and provide evidence for their decision-making in rural China.
