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To eradicate smallpox, each outbreak had to be stopped from spreading, by isolation of cases and vaccination of everyone who lived close by.
While chikungunya infection is often self-limiting and rarely fatal, the cholera outbreak is the more worrying, given the limited access to clean water and health facilities and a poor communication infrastructure that complicates efforts for tracing, diagnosis and isolation of cases.
However one highly plausible reason for the increased secondary attack rate observed in this study was due to voluntary isolation of cases and quarantine of household contacts.
This discrepancy suggests that the process of infecting other people can be terminated by isolation of cases, or by exhaustion of susceptibles in the local environment, as well as by a decline in viral shedding.
Studies using computational models have examined roles of border controls, internal travel restrictions, treatment and prophylaxis with antivirals, isolation of cases, quarantine of household members, school closure, and partially effective vaccine on limiting outbreak sizes [1] [7].
Isolation of cases: Isolation of cases reduces their contact rates.
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These might range from better compliance with hygiene protocols to strict isolation of case-patients and quarantine of their contacts.
NPIs that have been identified as potential mitigation strategies include voluntary isolation of case-patients, voluntary quarantine of contacts of cases, and social distancing of children and adults.
Measures that will enable the early detection and isolation of case-patients and quarantine of contacts should be the focus of resource allocation.
This result strongly validates the current infection control measures to contain the spread of this virus, i.e., early identification and isolation of case-patients.
Our findings suggest that isolation of case-patients and prophylactic treatment of contacts may reduce transmission of meningococcal disease during epidemics.
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CEO of Professional Science Editing for Scientists @ prosciediting.com