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These genomic variations are indicative of genetic drift during geographic isolation, adaptation, and coevolution of the pathogen within different ethnic groups of human population [ 5, 6].
Also, although the production of autogenous inactivated vaccines as described in this study may appear too elaborate and costly (virus isolation, adaptation to cell culture, high dose needed,…), further optimization of the production process should make future use of these vaccines more feasible.
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If so, genetic differentiation may be determined more by isolation by adaptation (local adaptation) than isolation by distance (dispersal), with populations in the most heterogeneous rather than least connected habitats showing the highest genetic differentiation (Nosil et al. 2009).
Moreover, the evidence for heterogeneous genomic divergence at the genome-wide level from this study aligns with the results of our earlier study that found a clear signal of isolation by adaptation, suggesting adaptive divergence has been reducing gene flow at a genome-wide scale [ 47].
Its distinct coat pattern perhaps evolved rapidly because of geographical isolation and/or adaptation to a drier environment.
Although sympatric isolation and adaptation to cattle and deer have been suggested for R. microplus in New Caledonia [ 5], ticks easily adapt to feeding on new host species [ 6].
However the relative contribution of geographic isolation, local adaptation and interspecific interactions, including hybridization, in the generation of these species assemblages is rather unclear.
Although not explicitly tested, there was little evidence for such isolation by adaptation, despite large differences in environmental conditions between the Antarctic Peninsula and South Georgia (Murphy et al. 2013).
Such isolation by adaptation [ 95] is likely facilitating drift in neutral loci by reduced gene flow as a general barrier mechanism [ 96], and even neutral markers may detect adaptation in the face of intermediate migration [ 97].
Two main factors could lead to the strong genetic structure observed: long-term fluctuations in climatic conditions that affect the strength of phenological isolation, and adaptation to local conditions that lead to habitat isolation.
This is consistent with the theory of isolation by adaptation and the later stages of ecological speciation where gene flow is small or nonexistent (Feder, Egan, et al. 2012).
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