However, most published works in the field of MSWM complete their study with an analysis of isolated case studies.
The triple helix should not be understood as a generally valid theoretical structure, but rather as a systemic approach " which creates a common analytical framework for the mostly isolated case studies in this area" (Ortiz 2013: 50, translated).
However, except for isolated case studies experimental evidence for an IgE-mediated pathomechanism of DF hypersensitivity is lacking.
This relationship can now be seen as broadly general, but it was already incipient in isolated case studies of DNA-protein interactions, both specific and non-specific.
A framework synthesis approach allows a team to go beyond insights from isolated case studies by seeking to identify what is generalisable across multiple settings.
Until recently, reports were limited to isolated case studies and small open-label case series (Mashima et al., 1992, 2000; Cortelli et al., 1997; Carelli et al., 1998, 2001; Barnils et al., 2007).
An action research approach with a motivated partner organisation has much to offer, including potential for breakthrough performance gains in practice, rather than in theory, in isolated case studies, or in the laboratory.
Such a specific protein history is unlikely to be an isolated case as studies on other enzymes suggest [ 39, 93, 174- 177].
