In conclusion, there is very large between-region variability in AFO prevalence among never-smokers in the CKB, which highlights the importance of nonsmoking risk factors in the aetiology of AFO.
The random effects summary odds ratio yielded a mere p = 0.015, as compared with p = 4.3×10−7 by Mantel-Haenszel calculations, and there was very large between-study heterogeneity (75%).
The reason for this diversity is that there was very large between-study heterogeneity in the effect sizes (I2 of 82% [95% CI: 73-89%] and 80% [95% CI: 70-86%], respectively, for the two polymorphisms; Q-test p-value <0.001 for both polymorphisms), and this makes the fixed effects calculations less reliable.
For closely similar structures the difference between the most consistent (beta strands) and least consistent (π helices) is very large, as is the difference between these and the background level of consistency.
As a result, while the difference in the impact of trust in the home country between the United States and Australia is very large for women (−0.514), it is small for men (−0.107).
While all civil wars involve the loss of life, there is very large variation between and within conflicts in how many people are killed.
Learning to perform tasks like these is complicated because the space of possible programs is very large, and the connections between the natural language and the resulting programs can be complex and ambiguous.
Plato wrote of Socrates saying the world is very large and those who dwell between Gibraltar and the Caucasus — in his memorable imagery — live "in a small part of it about the sea, like ants or frogs about a pond, and that many other people live in many other such regions".
If the number of cells needed to cover a study area at the necessary resolution in a raster cell zone system is very large, the number of interactions between non-adjacent cells make the model computationally infeasible.
In this paper we do not report t-statistics for these mean squares since the sample size is very large and hence any deviation between model and data would be reported as a statistically significant deviation [ 36].
