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Much of this variability across disorders and within RTT is likely due to genetic modifiers that is, variants of genes that are a part of MeCP2-regulated pathways.
Second, although we have been quite successful in identifying specific disease-associated genes in two domains - Mendelian disease (germline mutations) and cancer (somatic mutations) - we remain poorly equipped to interpret sequence variants that are observed in individual patients, that is, variants of uncertain significance (VUS).
Similar(58)
This is variant of the majority manuscripts.
Several are variants of Hujar's best-known subjects.
Eleven are variants of "new" ("anew," "renew," "renewal").
The drones will be variants of the Reaper, the more advanced version of the Predator.
Some are variants of BCG, designed to prompt a more efficient immune response.
The pavilion museum and the laboratory are variants of the boutique.
These tiny tasters are served on bent silver spoons, and most seem to be variants of goose liver.
Many of these treatments – verified by dozens of randomised controlled trials – are variants of cognitive behavioural therapy, though other therapies such as counselling are effective for certain problems.
Veronese's shadings are variants of the hues they inflect, and his contours aren't so much boundaries of form as sinuous frontiers where paint changes color.
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CEO of Professional Science Editing for Scientists @ prosciediting.com