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However, whether one pathway is upstream of the other remains unclear.
Our work suggests that a key pathophysiologic event in ALS is upstream of aggregate formation.
Thus, HIF target gene activation is upstream of mitochondrial function and is responsible for altering mitochondrial activity.
Ludmila Prokunina-Olsson, Thomas O'Brien and colleagues report the discovery of a new gene, INFL4, encoding interferon-λ4, that is upstream of INFL3 (INFL3).
Levin M, Mercola M. Gap junction-mediated transfer of left-right patterning signals in the early chick blastoderm is upstream of Shh asymmetry in the node.
The first one is upstream of the previously designed initiation translation site localized in the rat calpastatin L-domain.
The connection between the cassette and the final product vial is upstream of the sterilizing filter.
However, RhoA, which is upstream of ROCK in the signaling pathway, was still activated (Fig. 2E).
The antioxidant response element is a cis-acting enhancer sequence that is upstream of many phase II detoxification and antioxidant genes.
Our study shows that STK35L1 is upstream of CDKN2A.
Boehning et al. showed also that Ca2+ elevation is upstream of caspase-3 activation [3].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com