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takeout is upregulated in a variety of long-lived flies, and extends life span when overexpressed.
The miR-17~92 miR-17~92(microRNAluster host gene is upregulated in a broad spectrumiRNAhuman cluster including colorectal cancer (CRC).
Cathepsin L is a cysteine protease that is upregulated in a variety of malignant tumors and plays a significant role in cancer cell invasion and migration.
During monocyte-to-macrophage differentiation, ERα is upregulated in a time-dependent manner.
In the cochlea, Atoh1 is upregulated in a base to apex gradient, starting around E13.5 [32], [32].
These data confirm that dCK is upregulated in a setting when HuR is overexpressed and downregulated in a setting when pp32 is overexpressed.
It is expressed in mouse PGCs, and its expression is upregulated in a female-specific manner when male-specific de novo methylation of the PGC genome occurs [37].
It has been reported that vimentin is also expressed in motor neurons, and its expression is upregulated in a number of animal models for MNDs as the disease progresses [57].
Studies in Bacillus cereus revealed that a purA mutant is unable to effectively form biofilms or release eDNA, and the expression of purA is upregulated in a biofilm versus planktonically grown cells [35].
However, the issue of the CyP role in tumorigenesis is complicated by the observation that CyP-A is upregulated in a variety of tumor models, where it is involved in cancer cell survival, resistance to chemotherapeutics and metastasis [41], [48], [49], and that CsA treatment induces tumor necrosis and abrogates metastasis formation [45].
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Moreover, expression of DNA methyltransferase 3A (DNMT3A), a key enzyme for de novo DNA methylation, is upregulated in A. phagocytophilum-infected neutrophils ex vivo [ 9].
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