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A recent analysis based on three-species alignments of chicken, turkey, and zebra finch has reported evidence that synonymous sites may be under significant constraints (Künstner et al. 2011).
Moderately beneficial or deleterious passenger mutations (with selection coefficients − σ ˜ < σ < σ ˜ ) are reduced to near-neutral fixation probabilities, and only strongly deleterious mutations (with σ < σ ˜ ) are under significant evolutionary constraint (Schiffels et al. 2011).
We'll have to give Section 199A another read, this time with the mindset that the people who were drafting the provision were under significant time constraints, and simply doing the best they could.
The main conclusion from this study is that 4-fold degenerate sites of avian genes evolve under significant constraint, at least when constraint is estimated using divergence in ARs as a neutral reference.
Due to their professional engagements, such user groups are under significant time and location constraints, often preventing them from attending a professional training course.
Both were under significant pressure to succeed.
The nature of the current Syrian environment is a significant constraint on any investigation.
Voluntary reporting has been a significant constraint on past attempts to count police use of force.
But there is little question that fear of aerial interdiction has been a significant constraint on Peruvian drug production.
61 percent said budgets were a significant constraint when meeting the cybersecurity challenge.
This lower limit has been a significant constraint in cosmology.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com