Sentence examples for is transporter dependent from inspiring English sources

Furthermore, metformin absorption is the rate-limiting step in drug disposition because absorption is transporter dependent and saturatable, which causes bioavailability to diminish as dosage increases (7, 9).

In this respect, it is well known that 1), substrates have to be transported from the lipid bilayer to the transporter protein before a capture mechanism of the drug by the inner leaflet of the cytoplasmic membrane (14); and 2), the activity of transporter is critically dependent on the surrounding lipid bilayer environment (15, 16), which may be modified by drugs.

Lastly, over-expression of the caf5 locus mutation has been described to enhance the protein levels of an ABC transporter, Caf5 [11]; the expression of this transporter is dependent on Pap1 [16].

Similarly, the mechanism of action of ABC transporters, although still not fully unveiled, is highly dependent on transporter-membrane interactions, which play a principal role in transporter stabilization and substrate recognition.

ASC amino-acid transporter 2 (ASCT2) is a Na+-dependent transporter responsible for the transport of neutral amino acids, including glutamine, leucine, and isoleucine (Kekuda et al, 1996).

Such ion homeostasis is dependent on transporters, including ion-coupled transporters like the Na+/Ca2+ exchanger (NCX), Na+/Ca2+, K+ exchanger (NCKX), cation/Ca2+ exchanger (CCX) and H+/Cation exchanger (CAX), which are members of the CaCA superfamily (Cai and Lytton 2004).

Another type of predicted Mn transporter is an ATP-dependent ABC-type transporter (DR2283-DR2284, DR2523) [29].

Both microarray transcriptome analysis and computational prediction of RpoN promoter elements concluded that the dcuB gene, which encodes the fumarate/succinate exchanger (C4-dicarboxylate transporter), is RpoN-dependent.

(1190) The activity of PGP, and probably all transporter proteins, is heavily dependent on the lipid environment.

The second mechanism is the ABC transporter-dependent pathway.

Transcription of all but three cation transporters is not salt dependent.