Our data suggest that TDP43, like other essential RNA binding proteins67, is trafficked through partially redundant and overlapping pathways, ensuring that TDP43 nuclear export will proceed unchecked even if one or more pathways are blocked.
A co-founder of the environmental watchdog group Coalition Lampogno, he revealed how rosewood is trafficked through Maroantsetra port with the connivance of local businessmen supported by powerful national politicians.
A quarter of all cocaine consumed in Western Europe is trafficked through West Africa, according to UNOCD, for a local wholesale value of $1.8bn and a retail value of 10 times that in Europe.
The S protein of SARS-CoV that forms its surface coat, is produced in large amounts in infected cells and is trafficked through the ER, modulates UPR [4].
As APP is trafficked through the secretory pathway, a series of glycosylation events occur leading to a mature, or fully glycosylated, protein with slower mobility on SDS-PAGE.
In the developing wing imaginal disc epithelium, DEcad is trafficked through both Rab5-positive early endosomes and Rab11-positive recycling endosomes, in a process that is dynamin, Rab11, and exocyst dependent [33].
In normal, regulated secretion, ProCT is trafficked through the Golgi apparatus and then packaged into dense-core secretory vesicles [ 26, 27].
However, in glandular and neural tissues, neuroserpin is trafficked through the regulated secretory pathway, stored in dense core vesicles and secreted upon stimulation (22– 22).
Additionally, delivery agents may cause harmful side effects because the introduced RNA is trafficked through pathways that expose them to the innate immune system.
However, additional host factors shuttling from the plasma membrane to the endosomal compartment are required because, subsequent to internalization, the virus utilizes the conventional endolysosomal pathway and is trafficked through early and late endosomes before membrane fusion takes place.
