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The phrase "is totally different from" is correct and usable in written English.
You can use it to emphasize a significant distinction between two subjects or concepts.
Example: "The new policy is totally different from the previous one, which caused confusion among the employees."
Alternatives: "is completely distinct from" or "is entirely unlike".
Exact(60)
"Sean is totally different from John.
My process is totally different from book to book.
"A31 is totally different from U.F.P.J.," Mr. Laursen explained.
This nuclear plant accident is totally different from other disasters.
"Children's publishing is totally different from adults," Mr. Gernert said.
This is totally different from urban areas where friendliness ranks right below "flosses regularly" in importance.
"This is totally different from what we expected," he said softly.
"There is a sense of discovery that is totally different from all our other galleries".
So for me, she is totally different from anything I've done".
But that doesn't matter, because your future is totally different from other people's futures".
"Al Gore is totally different from his public persona," said Mr. Campbell.
More suggestions(13)
is utterly different from
is wholly different from
is really different from
is quite different from
is fundamentally different from
is fully different from
is entirely different from
is thoroughly different from
is definitely different from
is categorically different from
is radically different from
is altogether different from
is complete different from
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com