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The best characterized role for ubiquitination of membrane receptors is to negatively regulate signaling by targeting receptors for lysosomal degradation.
We propose that an additional role for TNF in DMD is to negatively regulate satellite cell activation through Notch-1 suppression.
Taken together, these findings indicate that the function of endogenous dSmad2 is to negatively regulate vein formation in the Drosophila wing.
A key role of LKB1 is to negatively regulate the activity of mTOR complex 1 (mTORC1).
The principal biological activity of MSTN is to negatively regulate growth of muscle fibres [ 2].
The output of this complicated signaling system is to negatively regulate MrpC by increasing its proteolytic turnover [ 17, 49].
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UV exposure is known to negatively affect immune system functions.
"It's difficult to negatively surprise the market beyond what we saw on Sept. 11".
And I think that's going to negatively affect them and their company.
Poor adherence to ICT was documented to negatively impact survival.
Indeed, it was shown to negatively regulate cellular growth [ 69].
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