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One of the main focuses of clinical research now is to define valid and reliable biomarkers of disease onset and progression that can be of use in future treatment trials.
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The ultimate goal, after testing the candidate markers presented here in a larger, rigorous case control classification study in patients with a well-defined type of lung disease will be to define valid markers that help with lung disease diagnosis, disease progression, or response to drug therapy.
The second premise is to define a set of valid outcome measures that are sensitive to the possible impact of the intervention.
The aim of this paper is to define a wheelset track interaction model valid in a frequency range up to 1500 Hz and hence suitable for the investigation of typical problems related to high-frequency train track interaction such as short-pitch rail corrugation.
Although these facts are frequently ignored by applying retrospective blinded reading to obtain an assessment of comparative sensitivity, specificity and accuracy, a scientifically more valid approach is to define the prevalence of disease in the population being studied and the negative and positive predictive value of the PET result in this group of patients.
Whereas the algebraic values are elements of an algebraic structure and referents of formulas, the logical value true is used to define valid consequence: If every premise is true, then so is (at least one of) the conclusion(s).
On the contrary, GM data can be used to define valid types, especially in haft modules rather than whole points to control for resharpening allometry.
To define the boundaries of the full system, it is necessary to define a valid range for the target factor.
An acceptable assay is based on linear regression parameters that must be met to define a valid assay.
Therefore, any pdf for positive random variables can be used to define a valid test function η t through its corresponding cdf.
The posterior probability density function of distribution of state vector and similarity between the candidate and reference observation of an object are used to define the valid measurement of the reliability to model updating during tracking.
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