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The pathologic inclusions are composed of a small N-terminal cleavage product of mutant htt that is thought to terminate N-terminal to amino acid 115 [this fragment has been referred to as cleavage product-A (Cp-A) or cleavage product-1] (16– 19).
Biosynthetically, the creation of the polyisoprene begins with the compound trans,trans-farnesyl pyrophosphate, and is thought to terminate by esterification of polyisoprenyl pyrophosphate.
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Reciprocal connections are present between PMd and prefrontal, parietal as well as premotor areas70 and these projections from prefrontal and pre-arcuate areas are thought to terminate in superficial layers of PMd39.
The primary role of endocytosis was thought to terminate activation of RTKs, and the attenuation of the receptors by endosomal degradation was even proposed to have a tumour suppressor role (Kim et al, 2002a; Zhang et al, 1997).
After a substrate becomes committed to future incorporation, however, the timing of phosphodiester bond synthesis is delayed, as indicated by quench flow studies using HCl or other denaturing quenching agents, which are thought to terminate the RNAP reaction mechanism immediately upon mixing.
For many membrane receptors, phosphorylation and ubiquitylation lead to internalization, which is thought to ultimately terminate signal propagation.
Using three-dimensional inversion of gravity data, we resolved a low-density structure that likely represents the active magma reservoir of Aso volcano, the presence of which is thought to have terminated the rupture of the 2016 Kumamoto earthquake.
This conformation of the mRNA is thought to promote recycling of terminating ribosomes for a new round of translation at the 5′-end and, thus, support efficient translation.
The down-regulation of WUS in the terminating floral meristem is thought to be regulated by AG [ 46, 47].
For E. coli approximately half of the transcriptional units are thought to be terminated by a rho-independent terminator [ 31].
Finally, the inferred ramp shape of our eskers has counterparts in the deglaciated landform record, notably eskers of type I III described by Brennand15, which are thought to have formed by subaqueously terminating conduits.
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