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For this reason, combining early viral suppression using ART with cellular immunotherapy is thought to augment HIV-specific immune response.
This effect is attributed to warm-up angina, which is thought to augment the innate resistance of the myocardium to an ischaemic insult [ 51, 52].
Inhibition of HDACs is thought to augment gene transcription, as the histones cannot be changed to their highly condensed, hypoacetylated form (Kim et al, 2003).
The lysine residues in both transcription factors are subjected to acetyl group addition, which is thought to augment assembly of the transcriptional machinery and to enhance gene transcription [ 35].
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Growth factors are believed to establish auto-, para- and juxtacrine loops that are thought to augment and amplify initial steroid hormone signals.
In the context of suppressing primary tumor growth by targeting the tumor vasculature, concurrent Ang1 inhibition was thought to augment the activity of Ang2-specific inhibition (Falcon et al, 2009; Coxon et al, 2010), but metastatic disease was not modeled in these preclinical studies.
The monoclonal antibody ipilimumab, approved in over 40 countries to treat advanced melanoma and currently under phase 2 and 3 investigation in prostate cancer, is thought to act by augmenting immune responses to tumors through blockade of cytotoxic T-lymphocyte antigen 4, an inhibitory immune checkpoint molecule.
AGR2 is thought to promote tumor formation by augmenting cell viability, anchorage-independent growth, and invasive properties of the biliary tract cancer cells.
Indeed, the ability of cycloheximide to augment Fas-mediated apoptosis is thought to reflect the importance of endogenous production of inhibitors of apoptosis.
During exercise, IL-6 is thought to act in a hormone-like manner to mobilize extracellular substrates or augment substrate delivery [ 85].
Trafficking of MSC to the injury site and their subsequent participation in the regenerative process is thought to be a natural healing response that can be imitated or augmented by enhancing the endogenous MSC pool with exogenously administered MSC.
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