The number of sub-matrices, S, (possible δ-biclusters) in an M × N matrix is: (2) S MN = (2 N - 1)(2 M - 1) In such an exponential search space an exhaustive search through all possible sub-matrix solutions is NP-hard [ 16] and therefore impracticable in large gene expression data matrices.
"On the other hand, to elevate doubt into a political program is distinctly impracticable".
In addition, ML estimation with bootstrap application is computationally impracticable in the present case because of the size of the data set.
This is absolutely impracticable.
However, in humans there are obvious restrictions because access to the inflamed tissues or regional lymph nodes is often impracticable.
Direct estimation, based on data from populations exposed to low doses, is usually impracticable because of sample size requirements.
Other diagnostic options, such as sputum cytology or positron emission tomography (PET) scanning, will be reserved for cases where either bronchoscopy or needle biopsy is deemed impracticable.
In the oldest subjects, the above mentioned techniques are not easily applicable and a 24-hour urine collection for creatinine clearance is often impracticable [ 13].
Thus, it is impracticable to establish a fat percentage profile for all weight classes.
