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If the loss of amyloid formation is the key defect in Als5pV326N, then chemical inhibition of amyloid formation should show similar effects, and the residual activity of the Als5pV326N protein should be resistant to the inhibitors.
Moreover, recovery from mitosis-inhibition by monastrol revealed a high incidence of merotelic attachment that was nearly identical with condensin depletion, Aurora B inactivation, or both, indicating that the Aurora B dysfunction is the key defect leading to chromosome missegregation in condensin-depleted cells.
This effect was attenuated when adjusted for Matsuda ISI but abolished after adjustments with DI30 suggesting insulin secretion is the key defect leading to type 2 diabetes after GDM pregnancy.
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However, impaired insulin secretion due to beta cell failure seems to be the key defect leading to the deterioration of hyperglycemia after a pregnancy affected by GDM.
When aberrant RLR signaling is activated, the key defects may be cell autonomous.
Impulses occurring at specific period is the key characteristic of corresponding defect.
Companies use it to raise quality and efficiency by spotting and removing causes of defects, and here measuring is the key, whether it is measuring defects, waste or results.
Controlling different types of defects is the key to improve the catalytic performance [27].
The existence of hooking defects is the key factor to reduce the fatigue strengths.
Controllable osteoinduction maintained in the original defect area is the key to precise bone repair.
The former implies that the local intensity distribution in the neighborhood of a particular structural state, e.g., atomic coordination surrounding a defect site, is the key measure by which we perform detection of local structural states.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com