LPV/r soft-gelatine capsule and oral solution were the first formulations approved for use in children.
Two months later, Born and Jordan finished their paper, "On Quantum Mechanics", which is the first rigorous formulation of matrix mechanics.
To our knowledge, our inclusion of an amino acid-weighted representation of a cell substructure, i.e. the cellulosome, as part of the biomass equation is the first such formulation used in constraint-based models.
The underlying mathematical construct is the first exact, generalized formulation that directly models spatial contiguity in optimal reserve selection.
Omegaven™ is the first n3-PUFA formulation approved for the intravenous use in humans.
This is the first polymeric micelle formulation approved by FDA and is reported to be superior in terms of safety and tolerability compared to other marketed formulations (ethanol/Cremophore EL).
This is the first extended-release formulation of topiramate, which was designed to have a lower Cmax and delayed Tmax compared with immediate-release formulations, but with a similar AUC.
12 ATX-101 demonstrated efficacy in the reduction of SMF with appropriate tolerability in phase I and II studies, 15– 18 and is the first pharmacological adipocytolytic formulation to be investigated in large-scale randomized, controlled clinical studies.
IDegAsp is the first analog co-formulation that contains both long- and rapid-acting insulins, thereby providing the total daily basal insulin requirement as well as the bolus insulin requirement for one main meal.
