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It is the first compound reported to inhibit Pfmrk at the micro molar range.
This derivative is the first compound exhibiting low micromolar to nanomolar activities for these three targets.
To our knowledge, SPD is the first compound known to have mixed D1 antagonist antagonist properties.
We found that 4 is the first compound known to induce an irreversible vesiculation of these membranes.
The inhibitory activities determined for a series of structurally related analogues support the proposed binding mode of palinurin, which is the first compound described to target this allosteric site.
Zelnorm, which is sold in Europe as Zelmac, is the first compound in some time with the potential to be a blockbuster.
Similar(42)
NBS is the third compound that significantly inhibits the TPPI activity without affecting the active site.
SCYX-7158 (143) is the second compound for HAT that has recently entered human clinical trials.
Dr. Jameson said that if saccharin was taken off, it would be the first compound to be removed by means of a review process as rigorous as the one required to put a substance on the list in the first place.
As a result of these and other data described here, 3k (APD668, JNJ-28630368) was the first compound with this mechanism of action to be progressed into clinical development for the treatment of diabetes.
Sildenafil, a specific inhibitor of phosphodiesterase 5 (PDE5), was the first compound to induce migraine-like headache in a human headache model without a concomitant artery dilatation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com