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Moreover, TPC1 and the endosomal population to which it is targeted, when stably overexpressed, exhibit a more restricted spatial distribution in HEK-293 cells than does TPC2/lysosomes and in a manner that mirrors the Ca2+ signals observed in cells stably overexpressing TPC1.
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Almost all are targeted when empty to avoid casualties.
Arts programs have historically been targeted when fiscal constraints require government belt-tightening.
Thus, several signaling pathways should be targeted when designing therapeutics for HL.
One employee told the group he felt "that black customers were targeted when it came to stealing", the report said.
Many never received the letters and only found out they had been targeted when they checked their bank accounts.
These findings suggest that CYP26A1 is the P450 isoform that should be targeted when designing RA metabolism blocking agents.
Neighborhoods in Damascus have been destroyed by government forces, and bread lines in several towns have been targeted when the concentration of civilians would be at their highest.
As the supply and utilization of oral cholera vaccines grows, critical questions related to herd immunity are emerging, including: who should be targeted; when should revaccination be performed; and why have cholera outbreaks occurred in recently vaccinated populations?
The disagreement is all about thresholds, what counts as predation, which wolves should be targeted when a pack is killing cattle, and who has the right to pull the trigger.
As Kaaryn Gustafson, professor at the University of Connecticut school of law and an expert on the history of welfare politics, told me: "The poor often end up being targeted when the economy is bad.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com