These data demonstrate that PAK1 inhibition itself is sufficient to activate PPARγ transcriptional activity.
The resulting impairment in channel activity is sufficient to activate the downstream voltage-gated calcium channels and thus trigger unregulated insulin secretion.
This result suggests that under the conditions tested the native FadD activity is sufficient to activate the available FAs to their respective acyl-CoAs.
To further determine whether the dimerization of Fu is sufficient to activate the Hh pathway, we examined the activation of the Hh pathway by dimerized Fu in vivo.
So why would invasive melanoma cells require more Src and/or PKC activity if αvβ3 integrin is sufficient to activate these two pathways?
In normoxic condition, PIAS4 alone is sufficient to activate STAT3, NF κB, ERK and subsequently transcriptional activation of MYC, Cyclin D1, VEGF, and JMJD1A.
A plausible explanation is that since Src is constitutively associated with the cytoplasmic domain of the β3 subunit, cilengitide-induced αVβ3 'outside-in' activation and unclasping of the αVβ3 cytoplasmic domains is sufficient to activate Src.
Small amounts of carbon dioxide and helium in the ambient is sufficient to activate the phenomena.
Put differently, those actions that best ensure the context is sufficient to activate the sought after preventive mechanisms.
tepidum is sufficient to activate calcium-ion binding and the extent of red-shifting increases with the proportion of Tch.
Therefore, in the presence of ethanol, the normal body temperature of 37°C is sufficient to activate the channel and to promote neurogenic inflammatory responses [34].
