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Anyone expecting some sort of brilliant metacommentary about the state of US politics and race and gun issues is going to be disappointed because there is barely a story at all, much less one that is substantive enough to make any actual points.
Studies are needed to ascertain whether single dose per day is substantive enough to modify the bacteria flora.
The resource implications of either of these approaches could be substantial, and the Cochrane Reviewer's Handbook recommends the establishment, for each review, of "guides addressing when new research evidence is substantive enough to warrant a major update or amendment".
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Robert E. Rubin, the United States Treasury Secretary, may believe that the Japanese promises are substantive enough to deserve a big-buck intervention.
The structure need not be elaborate or even permanent, but it must be substantive enough to indicate a serious commitment to those who use it.
"The likelihood is that those few anomalies, which exist in every election in the world, will not be substantive enough collectively to change the apparent results of this election," Mr. Carter said.
"It is conceivable that the decisive outcome to the election could encourage a pick-up in instructions to agents and ease some of the recent upward pressure on house prices, but it is doubtful that this will be substantive enough to provide anything more than temporary relief.
In the face of these difficulties, some philosophers have sought to develop accounts of the base property that are substantive enough for ethical supervenience to do dialectical work, but avoid some of the difficulties just sketched.
No moral claim that is plausibly offered as actually accepted by all, or nearly all, people can possibly be substantive enough to help settle on one view rather than another as better justified.
Mr Evans said he believed all they had was a photograph of the pair together - so asked Mr Coulson why the evidence he claimed to have was substantive enough to run such a major story.
The complaints then passed to Judge Karen LeCraft Henderson of the DC Circuit, who concluded that more than a dozen of the complaints were substantive enough to warrant investigation and she referred them to Chief Justice Roberts.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com