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It turns out that despite the fact the efficient algorithms for estimation of one-sided models exist, the analogous two-sided problem is substantially more difficult.
For adult C.elegans, however, the cell labeling task is substantially more difficult.
More practically, PBIS is substantially more difficult to even identify, let alone correct.
The further assumption, however, that exclusive paternal investment straightforwardly implies net direct benefits for females, is substantially more difficult to justify.
In contrast, proteomic analysis is substantially more difficult given the increase in biochemical complexity when considering proteins as opposed to nucleic acids.
Finding the combination of rate classes using the greedy algorithm described above is substantially more difficult as the combinatorial complexity increases; therefore, we employ a CHC-GA to search through the parameter space.
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"If we try to find a student to do work part time in our administrative offices it's substantially more difficult than five years ago," Mr. Serpe said.
All of these sources of credit would have been substantially more difficult – and in many cases impossible – to access if our financial system had been allowed to collapse.
But Mr. Greenfield stuck with his sell recommendation for the company's stock, saying he believed the next 12 to 18 months would be "substantially more difficult for Disney than investors are currently anticipating".
Although the panel is not scheduled to issue its final report until October, the interim report, released yesterday, highlighted a number of issues it plans to study further: *The June test was "substantially more difficult" than the test a year earlier, as many students and teachers had claimed.
Gone are the days when Sony's machine was substantially more difficult to program for than Microsoft's.
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